P53 and breast cancer review free
The present paper aims to provide updated information on p53 regulation and function, with specific interest on its role in breast cancer. Discover the world's research 15 million members
p53 mutation is the most common genetic abnormality found so far in human cancer, and in breast cancer p53 mutationalteration is seen in up to 50 of primary carcinomas.
Mar 21, 2018 Thus, at present, mutant p53 cannot be recommended as a prognostic or therapy predictive biomarker in breast cancer. In contrast to the multiple reports on a potential biomarker role, few studies had until recently, investigated mutant p53 as a potential target for breast cancer treatment.
Aug 08, 2018 Safety and costeffectiveness are additional inevitable advantages of curcumin. This review summarizes the effects of curcumin as a regulator of p53 in BC and the key molecular mechanisms of this regulation. Keywords: natural products, apoptosis, p53, breast cancer
Jan 19, 1999 LiFraumeni syndrome (LFS) is a cancer predisposition syndrome associated with the development of the following classic tumors: soft tissue sarcoma, osteosarcoma, premenopausal breast cancer, brain tumors, adrenocortical carcinoma (ACC), and leukemias. In addition, a variety of other neoplasms may occur. LFSrelated cancers often occur in childhood or young adulthood and survivors
Feb 22, 2011 Here we investigate how p53 may affect response to antihormonal treatments, using estrogendependent breast cancer celllines with different p53 status. We show that p53 mutated cells were more resistant to cytotoxic effects of 4hydroxytamoxifen (OHT) compared to p53 wildtype cells.
p53 REVIEW ARTICLE TP53 Mutations in Familial Breast Cancer: Functional Aspects Milena Gasco, 1 Isik G Yulug, 2 and Tim Crook3, n 1Department of Medical Oncology, Azienda Ospedaliera San Croce e Carle, Cuneo, Italy; 2Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey; 3Ludwig Institute for Cancer Research, Imperial College Faculty of Medicine, Norfolk Place,
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