Role of mir 10b in breast cancer metastasis free
Role of miR10b in breast cancer metastasis. Breast Cancer Res. 2010; 12(5): 210 (ISSN: X) Ma L. Ninety percent of cancerrelated mortality is caused by metastasis. Current cancer treatments can control many primary tumors but rarely stop the metastatic spread. Accumulating evidence demonstrates that miRNAs are involved in cancer initiation and progression.
Oct 26, 2010 These results suggest that miR10b is a metastasispromoting miRNA in vivo in breast cancer. miR10b is also involved in the progression of other types of cancer. Antisense silencing of miR10b in NF1 malignant peripheral nerve sheath tumor
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that miR10b is a metastasispromoting miRNA in vivo in breast cancer. miR10b is also involved in the progression of other types of cancer. Antisense silencing of miR10b in NF1 malignant peripheral nerve sheath tumor cells reduced cell proliferation, migration and invasion [17. In esophageal cancer cells, ectopic expression of miR10b
One of the first miRNAs to be shown as having aberrant expression in cancer was miR10b. Since the inaugural study on miR10b, its role as a metastasis promoting factor has been extensively validated.
Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA10b (miR10b) is highly expressed in metastatic breast cancer cells and positively regulates
Oct 23, 2008 Ma et al. 1 report that overexpression of microRNA10b (miR10b) initiates invasion and metastasis in models of breast cancer and that its expression in primary breast carcinomas
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